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KMID : 0191120070220010167
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Journal of Korean Medical Science
2007 Volume.22 No. 1 p.167 ~ p.169
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Generalized Pustular Psoriasis and Hepatic Dysfunction Associated with Oral Terbinafine Therapy
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Kim Byung-Soo
Jang Ho-Sun
Jwa Seung-Wook
Jang Bong-Seok
Kim Moon-Bum
Oh Chang-Keun
Kwon Kyung-Sool
Kwon Yoo-Wook
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Abstract
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We report a case of 61-yr-old man with stable psoriasis who progressively developed generalized pustular eruption, erythroderma, fever, and hepatic dysfunction following oral terbinafine. Skin biopsy was compatible with pustular psoriasis. After discontinuation of terbinafine and initiating topical corticosteroid and calcipotriol combination with narrow band ultraviolet B therapy, patient’s condition slowly improved until complete remission was reached 2 weeks later. The diagnosis of generalized pustular psoriasis (GPP) induced by oral terbinafine was made. To our knowledge, this is the first report of GPP accompanied by hepatic dysfunction associated with oral terbinafine therapy.
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KEYWORD
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Psoriasis, Generalized Pustular Psoriasis, Liver Diseases, terbinafine
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